Duchess Bona of Savoy and Duke Gian Galeazzo Sforza commissioned the rebuilding. An earlier place of worship stood here in 879. Construction ran from 1472 or 1476, depending on whether the text or the infobox is followed, and ended in 1482. Giovanni Antonio Amadeo is credited with most of the work, including the facade. Some sources credit Donato Bramante, but recent documents suggest a minor role, and he is considered certain only for the sacristy perspective. The style is Italian Renaissance, with terracotta decoration.
The nave has two aisles and barrel vaults, with a dome at the crossing. A road behind the church left room for a choir only 3 feet (90 cm) deep. Bramante's painted trompe-l'oeil perspective replaced it, one of the earliest of its kind, though the article marks that claim as uncited.
A Romanesque bell tower predates the rebuild. It is an active Catholic church.

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