Pietro Lombardo and his sons Tullio and Antonio built the church, with groundbreaking in 1481 and completion in 1489. The 1480 decision to build followed a votive painting that stood near the home of the silk merchant Angelo Amadi. In 1484 the plans were expanded to add a convent for Poor Clare nuns. It is one of the first Renaissance-style buildings in Venice.
The facade has two stories with marble revetments and inlaid geometric motifs. The marbles include veined pavonazzetto, serpentine, yellow and red marble, and white Istrian stone. The article names no client and gives no dimensions.
Save Venice Inc. restored the church, in a seven-year campaign ending in 1997. The article gives conflicting start years and costs, with an estimate of 1 million dollars against a final 4 million. It belongs to the Chorus Association of Venetian churches.

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