Doge Giustiniano Participazio founded an earlier church here in the early 9th century, attached to a Benedictine nunnery. The present church was built by the Republic of Venice between 1458 and 1515. Antonio Gambello began it in the Gothic style, and Mauro Codussi finished the upper facade and interior in early Renaissance style.
The facade blends late Gothic and Renaissance, with arched windows and columns in Codussi's upper section. An ambulatory around the apse is lit by tall Gothic windows, which the article calls a Northern European feature unique in Venice. The earlier Gothic church still stands beside it.
Giovanni Bellini's San Zaccaria Altarpiece hangs here, with works by Tintoretto and Anthony van Dyck. The crypt holds the remains of several doges. Napoleon's forces suppressed the monastery in 1797. The article gives no hours.

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